THE SCIENCE BEHIND
The science behind
MarbleMat™ technology
MarbleMat™ technology
How MarbleMat™
Marbles work
Marbles work
MarbleMat™ Marbles are spherical particles (~2.5 mm) containing active ingredients dissolved in oil, enclosed in a solid protective acid-resistant shell. This shell helps the ingredient pass through the stomach without damage and release in the intestine, where absorption is more efficient.
Our technology works similarly to liposomes – increasing absorption, but the key improvement is that our particles have a solid layer that protects the active ingredients in the acidic environment in the stomach.
Our technology works similarly to liposomes – increasing absorption, but the key improvement is that our particles have a solid layer that protects the active ingredients in the acidic environment in the stomach.
Grounded in science. Proven in studies.
Reliable performance across conditions
At MarbleMat™, every innovation starts in the lab. Our patented Marbles technology has been validated through both in vitro and in vivo testing. In a case study using abiraterone acetate (a prodrug used in prostate cancer treatment), MarbleMat™ Marbles demonstrated 2.4× higher bioavailability than the commercial reference. Notably, they achieved the same therapeutic effect with a significantly lower amount of active compound — highlighting the system’s efficiency.
While the reference product showed a notable increase in absorption when taken with food (a known "food effect"), MarbleMat™ Marbles maintained stable solubility across both fasted and fed states. This means they can be taken at any time — with or without meals — without compromising efficacy. The marbles are also protected by an HPMC-AS polymer shell, preventing early dissolution in acidic environments and enabling controlled release in the intestine. This design ensures consistent, targeted delivery, tailored for both flexibility and precision.
How MarbleMat™ Marbles work
MarbleMat™ Marbles are spherical particles (~2.5 mm) containing active ingredients dissolved in oil, enclosed in a solid protective acid-resistant shell. This shell helps the ingredient pass through the stomach without damage and release in the intestine, where absorption is more efficient.
Our technology works similarly to liposomes – increasing absorption, but the key improvement is that our particles have a solid layer that protects the active ingredients in the acidic environment in the stomach.
Our technology works similarly to liposomes – increasing absorption, but the key improvement is that our particles have a solid layer that protects the active ingredients in the acidic environment in the stomach.
Grounded in science. Proven in studies.
Reliable performance across conditions
At MarbleMat™, every innovation starts in the lab. Our patented oil marble technology has been validated through both in vitro and in vivo testing. In a case study using abiraterone acetate (a prodrug used in prostate cancer treatment), MarbleMat™ Marbles demonstrated 2.4× higher bioavailability than the commercial reference. Notably, they achieved the same therapeutic effect with a significantly lower amount of active compound — highlighting the system’s efficiency.
While the reference product showed a notable increase in absorption when taken with food (a known "food effect"), MarbleMat™ Oil Marbles maintained stable solubility across both fasted and fed states. This means they can be taken at any time — with or without meals — without compromising efficacy. The marbles are also protected by an HPMC-AS polymer shell, preventing early dissolution in acidic environments and enabling controlled release in the intestine. This design ensures consistent, targeted delivery, tailored for both flexibility and precision.
The measurable difference
behind MarbleMat™
behind MarbleMat™
MarbleMat™ Advantage:
2.4× higher bioavailability at the same dose.
2.4× higher bioavailability at the same dose.
MarbleMat™ Advantage:
Higher water solubility leads to more effective absorption in the body.
Higher water solubility leads to more effective absorption in the body.
MarbleMat™ Advantage:
Flexible release design — from fast to sustained — tailored
to your formulation needs.
Flexible release design — from fast to sustained — tailored
to your formulation needs.
MarbleMat™ Advantage:
Controlled release in the intestine, not the stomach.
Controlled release in the intestine, not the stomach.
Randomized, single-dose, laboratory-blinded, 2-period, 2-sequence,
crossover bioequivalence study in rats.
crossover bioequivalence study in rats.
FaSSIF media pH 6.5, 200 mL, mini–paddles at 125RPM
Tested in vitro over 120 minutes; % release measured at multiple timepoints. Vitamin D dose 1.25 mg, demineralized water, 0.3% SDS, 100ml, 37°C, 150 rpm, n=3
0–30 min 10 mM HCl pH 2, 130 mL; 30–90 min FaSSIF pH 6.5, 195 mL; mini–paddles at 125RPM
In a rat bioequivalence study, MarbleMat™ achieved up to 2.4x higher, faster, and more efficient absorption compared to Zytiga in both fasted and fed states — with reduced variability.
In biorelevant FaSSIF media, Oil Marbles B achieved significantly higher solubility compared to Zytiga — reaching over 70% dissolved vs. less than 20% for the commercial reference.
Using MarbleMat™ technology, different formulations of Marbles achieved distinct release profiles — including both traditional and sustained release. Both formulations demonstrated significantly higher release compared to the commercial vitamin D oil formulation, enabling enhanced and controlled nutrient delivery.
Oil Marbles stayed intact in acidic (stomach-like) pH and rapidly dissolved in intestinal conditions. This preserves ingredient stability and supports absorption at the optimal site.
Faster and more complete dissolution
Better absorption and food effect elimination. In vivo
Different release profiles for optimal performance
Targeted release where it matters
Discover how the Marbles can benefit your business
WHITEPAPER
Download our whitepaper to see how MarbleMat™ can help your brand stand out with innovative, effective delivery technology.
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Technology composition
& Key characteristics
& Key characteristics
What’s inside every MarbleMat™ Marble
MarbleMat™ Marbles are precision-engineered particles designed for high performance, safety, and visual appeal. They’re made from 100% natural, biodegradable, food-grade materials and fully approved for use in food supplements under EU regulations (Non-Novel Food). Each marble is uniform in size (1–3 mm), allowing for accurate dosing and smooth capsule filling. Their lipid-based structure is optimized for poorly water-soluble compounds, enhancing absorption and ensuring controlled, sustained release directly in the intestine. Plus, they can be delivered in standard capsules or as stand-alone, capsule-free products.
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Contacts
Sales Department
E: sales@marblemat.com
E: sales@marblemat.com
For Media
E: media@marblemat.com
E: media@marblemat.com
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